Does mRNA in Jabs Really Produce S Spike from SARS-CoV-2?
The evidence points to something else altogether.
What proteins are actually generated after a Covid-19 mRNA “vaccine” injection? Somehow, this topic is not being talked about enough. It’s as if we are hypnotized not to see the very thing in front of our eyes. Why? Because we were told this so many times as-a-matter-of-fact, that we take it at face value. Hypnotized!
So, let’s question the unquestionable. Dive in! Unavoidably, the following text is in places a bit heavy on genetics, but one can still get the gist of it without specialized knowledge. If you have specific questions, please use the comments section below, and I will be happy to reply.
As it turns out, the mRNA instructions to build the "S spike" are far from the ones that should have been used if one truly wished to precisely program for SARS-CoV-2 spikes. For starters, in the Pfizer and Moderna mRNA jabs, every uridine residue in the mRNA is replaced with m1Ψ (N1-methylpseudouridine), which enhances immune evasion of mRNA once inside the cell so that this foreign mRNA is not degraded by the immune system, and thus the protein production is boosted compared to the unmodified mRNA. Coincidentally, this trick has been discovered and patented by Moderna itself in 2013, after a way to enzymatically replace uridine with m1Ψ has been discovered in 2012 (“Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs“). Also, appending a poly A tail to the mRNA, as done by Moderna and Pfizer, can increase its functional life up to tenfold (“Half-Life of mRNA”).
When you read a NIH-sponsored Covid-19 vaccine propaganda piece, “Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines,” it states:"Consistent with this, in the initial report where m1Ψ-containing mRNA was found to drive high levels of protein production, this was attributed in part to its ability to blunt TLR3 activation [immune response evasion]". Further, “these vaccines are nonreplicating mRNAs that naturally decompose and do not integrate into genomes [yeah, right: more on that below].“ We are constantly being mollified that this mRNA code stays in the transfected cells for a (unspecified) short period of time to do its work of S spike protein production, and then decomposes neatly shortly thereafter. Although no effort has been spared to make them last in the cell as long as possible? So, how long precisely? And how many spikes are produced, on average, by the transfected cells? Tell me if you ever saw this information, because I surely didn’t, not that I didn’t look.
At this point, we are on our own to make some snooping around. First, this article from 1990, “Direct gene transfer into mouse muscle in vivo“ states that, in mice, “after injection of the DNA luciferase expression vector, luciferase activity was present in the muscle for at least 2 months.” Not exactly same stuff as Covid-19 mRNA code, but there is a distinct possibility that this mRNA code, especially after being modified to evade the immune response, will work in the vaccinees for months on end. Prove me wrong with data. I posit that the prolonged elevated level of antibodies post Covid-19 mRNA vaccination (4-7 months), is the evidence that the mRNA is active in the vaccinees’ cells for that long, producing S spike proteins and causing elevated immune reaction on the ongoing basis. When this mRNA finally wears off, it’s time for a booster!
Thanks to Jim for pointing out, in the comments, this study from Aug. 2021: ”Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection”. It compares the levels and dynamics of antibody titers post Pfixer vaccination and in convalescent individuals. Although at 1 months after “vaccination” and a positive PCR test, the AB titers in vaccinated are 20 times higher. At 3 months, they are 5 times higher, on average. After 3 months, though, the rate of decline of AB titers in the vaccinated reaches 40% a months, while the AB titers in the convalescent, although being at a much lover level, decline at the rate of 4%. Six months after BNT162b2 vaccination 16.1% subjects had antibody levels below the seropositivity threshold of <50 AU/mL, while only 10.8% of convalescent patients were below <50 AU/mL threshold after 9 months from SARS-CoV-2 infection. Isn’t this difference in AB titer dynamics another evidence that we are not looking a normal vaccination-conferred immunity here, but rather something completely different? I posit, again, that we can observe here, from the AB titer dynamics, the actual dynamics of a die-off of the mRNA in the transfected cells of the “vaccinated”. How else would you explain such a stark difference in the AB titer dynamics?
After first publishing this post, I have just found additional related studies (4. in an excellent post by Dr. Paul Alexander, “Spike protein and components (S1 subunit) found 15 months in the blood after infection, suggestive of same for those vaccinated; can be catastrophic and was NOT studied by Pfizer or imposed by FDA“):
A study from May 2019: “A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection“. In their mRNA, they encoded a monoclonal antibody, then observed the titers of this mAb. Results: “Infusion of macaques with CHKV-24 mRNA achieved a mean maximal mAb concentration of 10.1 to 35.9 micrograms per milliliter, with a half-life of 23 days.“ Although the serum concentration of these mAbs seems to be falling off from 40μg/mL to 6μg/mL in about 25 days, so you be the judge:
A study from Aug. 8, 2015: “Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes”. One of the authors is Acuitas Therapeutics, the LNP inventor. This is what they have to say: “mRNA administered by various injection routes translated at high levels for up to 10 days depending on the dose and the site of the delivery. … When mRNA-LNPs were injected intramuscularly and intratracheally, similar to intravenous and intraperitoneal deliveries, a large portion of the luciferase activity was detectable in the liver, demonstrating systemic spread of the nanoparticles. … Interestingly, significant bioluminescent signal could be measured in the lungs and muscles, as well, with the latter lasting for up to 8 days post injection“. So, many days, rather than mere hours, of mRNA being translated at high levels. On top of this, they were aware of a systemic spread of the lipid nanoparticles after an intramuscular injection already in 2015! The Japanese-released Pfizer documentation confirmed this in 2021. Thanks, FDA, for due diligence in approving these jabs!
For completeness sake, this curve-ball study from May 2021 also must be mentioned: “Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients“: The team found that 11-of-13 participants had low levels of SARS-CoV-2 protein (S1 subunit) as early as one day post-vaccination. S1 subunit protein level peaked on average five days after the first injection. In all participants, the level of S1 protein declined and became undetectable by day 14. Spike protein was detected in 3-of-13 participants an average of 15 days after the first injection. After the second vaccine dose, no S1 or Spike was detectable.
(This work was supported in part by the Bill and Melinda Gates Foundation (grant number INV-017380). The authors acknowledge support from the following research grants for vaccine development: National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID), Welcome Trust, and International AIDS Vaccine Initiative (IAVI). AFO was supported by NIH T32HL007627)
Having ALL the main vaccination campaign perpetrators as study supporters makes the reported outcomes highly suspicious, and they, frankly, make no sense at all. Except to support the propaganda that the mRNA and the produced S spikes barely show up before disappering “in no time”, only to result in “lasting and highly protective” immunity to SARS-CoV-2. Or, at least, so they were saying in the first half of 2021.
A study from Nov. 15, 2021, “Cutting Edge: Circulating Exosomes with COVID Spike Protein Are Induced by BNT162b2 (Pfizer–BioNTech) Vaccination prior to Development of Antibodies: A Novel Mechanism for Immune Activation by mRNA Vaccines“: “…we analyzed the kinetics of induction of circulating exosomes with SARS-CoV-2 spike protein and Ab following vaccination of healthy individuals. Results demonstrated induction of circulating exosomes expressing spike protein on day 14 after vaccination followed by Abs 14 d after the second dose. Exosomes with spike protein, Abs to SARS-CoV-2 spike, and T cells secreting IFN-γ and TNF-α increased following the booster dose. Transmission electron microscopy of exosomes also demonstrated spike protein Ags on their surface. Exosomes with spike protein and Abs decreased in parallel after four months.“ During the course of a viral infection, host cells release exosomes and other extracellular vesicles carrying viral and host components that can modulate the immune response. This new study confirms, without any doubt, what I have been surmising all along! The S spikes are present in the “vaccinated” for at least 4 months post 2nd jab, and as they wane, so do the “famed” and “protective” antibodies to the S spike protein.
UPDATE 2022.02.14: The article “Long-term persistence of the SARS-CoV-2 spike protein: evidence and implications“ (Michael Palmer, MD and Sucharit Bhakdi, MD, 2021.12.21) arrive at the same conclusion as I do here: “While some specific claims made by Bansal et al. can be debated, the very long-lasting persistence of the spike protein in the body is convincingly demonstrated. Whether it is the mRNA encoding the spike protein that persists or rather the spike protein itself remains to be determined. Nevertheless, as long as the spike protein appears on either exosomes or apoptotic vesicles, it must be present on cell membranes; and as long as it is found there, the immune system will attack those cells. We must also note that the spike protein persists for at least twice as long as the participants of Pfizer’s farcical and fraudulent [9,10] ‘clinical trials’ were observed, on average, after the second vaccination . It follows that the reports on side effects which occurred in those trials cannot possibly be complete.“
Bruce K. Patterson et al. has published this article in June 2021: “Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection“. It presents the evidence that S1 spike protein is detectable in the non-classical monocytes, whose half-life is mere 7 days, for up to 15 months post Covid-19 infection in some “Long Covid” patients. But, according to Dr. Robert Malone’s tweets back in July, in the course of this study they were picking randomly six healthy “controls” out of healthy “vaccinated” individuals. To their astonishment, all six had S spikes in their monocytes 6 months after their “vaccination”, with one “control” having S spikes in 15% of monocytes! Which means that S spikes linger around or get freshly produced in the vaccinated for 6+ months, contrary to the official narrative that S spikes are cleared within 2 weeks of the jab!
Beside prolonging the life of the mRNA in a cell, another consequence of replacing all uridines with N1-Methylpseudouridines is the more error-prone translation of mRNA into proteins, as is expounded, e.g., in “Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines“: “As mammalian host cells attack unmodified exogeneous RNA [12,13], all U nucleotides were replaced by N1-methylpseudouridine (Ψ) [14,15]. However, Ψ wobbles more in base-pairing than U and can pair not only with A and G, but also, to a lesser extent, with C and U . This is likely to increase misreading of a codon by a near-cognate tRNA. When nucleotide U in stop codons was replaced by Ψ, the rate of misreading of a stop codon by a near-cognate tRNAs increased . Such readthrough events would not only decrease the number of immunogenic proteins, but also produce a longer protein of unknown fate with potentially deleterious effects.” What this says is that as mRNA is modified by replacing all U’s with Ψ’s, the translation of mRNA into proteins becomes more erratic. A sure-fire proof is that the stop codon in the mRNA (the 3-nucleotide marker in the mRNA that signals the end of the sequence to be translated) is being misread and ignored more often, which results in prolongation of the generated protein with unintended garbage. “A longer protein of unknown fate with potentially deleterious effects“ doesn’t sound too encouraging, does it? To further drive home this point, this 2019 article “Stop-codon read-through arises largely from molecular errors and is generally nonadaptive“ states that “stop-codon read-through arises mostly from molecular errors and is largely nonadaptive“, meaning that nothing good should be expected of these errors.
Wait, but there is more! In this Jul. 2021 article “Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines”, the author compares the “natural” S spike RNA from SARS-CoV-2 virus with the mRNA contained in Covid-19 vaccines, and discovers that the vaccine manufacturers deployed multiple “codon optimizations”, i.e. swapping of certain three-nucleotide sequences in the “original” virus RNA with different, thought to be equivalent, codons. On top of this, same article states that the choice of a stop codon in mRNA vaccines promotes errors in translation termination. This leads to decreased translation accuracy, meaning that the S spike proteins produced by the mRNA vaccines are often times not really the intended spikes, but rather some random protein garbage.
This article from Dec. 2020, “Covid-19 Pfizer Vaccine: The Worst-Case Scenario“, thus succinctly summarizes the information presented above: “The BioNTech/Pfizer BNT162b2 vaccine against Covid-19 is composed of an RNA having 4284 nucleotides, divided into 6 sections, which bring the information to create a factory of S Spike proteins, the ones used by Sars-CoV-2 (Covid-19) to infect the subject. After that, these proteins are directed outside the cell, triggering the immune reaction and antibody production. The problem is the heavy alteration of the mRNA: the Uracyl is replaced to fool the immune system, the letters of all codon triplets are replaced by a C or a G, to extremely increase the speed of protein production, replacement of some amino acids with Proline, the addition of a not clear sequence (3'-UTR), combined with alternative splicing, which is the possibility of errors in translation of the sequence and synthesis of proteins; they are not produced equal, but slightly different. All this can be the cause of many hereditary diseases and various types of tumors, from appearance to their growth, up to the metastasis formation. In essence, what will be created is anything but well defined as protein S Spike: just a transcription error, wrong production of amino acids, then proteins, to cause serious long-term damage to human health, despite the DNA is not modified, being instead in the cell nucleus and not in the cytoplasm, where the modified mRNA arrives. However, in this case, the correlation between speed of synthesis and protein expression with synthesis errors, as well as the mechanism that could affect the translation of the sequence remain obscure, as many trials are owned by BioNTech/Pfizer.“
Also, for the deep dive into the dangers of codon optimization, read “COPTIGATE - THE WORST DESIGN FLAW IN HUMAN HISTORY THAT IS IMPACTING YOUR HEALTH“ (Ehden Biber, Aug 20, 2021). The main point is, even if the “optimized” codon sequence produces the same protein, it tends to fold that protein in wrong ways. Protein misfolding "has been linked with neurodegeneration in Alzheimer and Parkinson disease, and many other pathologies." Read this post to discover references to relevant studies.
Wait, but there is more! Regardless of all the problems with the mRNAs used by Pfizer (and Moderna), there is evidence that about half of the mRNA contained in the “vaccines” is not really the advertised mRNA, but rather some soup of mRNA code that contains about 65% of the “advertised” mRNA (between 55% and 78%, depending on the vaccine batch), the rest being “truncated mRNA species” (or so they call them).
As I have already wrote in “Zeroing in on Gifts from “Science” to Humanity“, a leaked email from EMA to Pfizer in Nov. or Dec. 2020 identified “a significant difference in % RNA integrity/truncated species” between the clinical batches and proposed commercial batches—from around 78% to 55%. The root cause was unknown and the impact of this loss of RNA integrity on safety and efficacy of the vaccine was “yet to be defined,” the email said. It’s unclear how the agency’s concerns were satisfied. According to one of the leaked emails dated Nov. 25, positive news had come from an undisclosed source in the US: “The latest lots indicate that % intact RNA are back at around 70-75%, which leaves us cautiously optimistic that additional data could address the issue,” the email said. EMA told The BMJ that the levels of truncated mRNA “and the amounts of a potential protein produced by the truncated mRNA would be too low to constitute a safety risk.” How do they know? Trust us!
What about Johnson& Johnson vaccine, or AstraZeneca? Glad you’ve asked. Here’s an in-depth analysis of the J&J viral-vector jab: “Expert Report on the Johnson & Johnson COVID-19 Vaccine“ (Michael Palmer MD, Sucharit Bhakdi MD, and Wolfgang Wodarg, MD, “Doctors for Covid Ethics”, 2022.02.09):”The J & J vaccine is not a traditional vaccine but rather a form of gene therapy.”
And there you have it. Trust the science and get the jab, or two, or three. For now. It’s good for you!
Here are some of the immediate effects on the vaccinees’ immune systems, as seen by the practicing physicians: “A testimony of Dr. Ryan Cole“.
The cherry on the cake? “Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues”.
Another cherry is “Coronavirus gene findings are no cause for alarm, says leading scientist“: “Jaenisch’s study found the viral genes can make use of LINE-1, a common enzyme in the human body, to get into the nucleus and insert themselves in our DNA. The nucleus is protected by a lipid membrane, but not entirely sealed, allowing materials to come in and out with the help of some agents such as LINE-1.“ Jaenisch’s reason not to worry? “One could speculate that such an integration, if indeed happening, might result in more long-term expression of the antigen [a substance that causes the immune system to create antibodies] and thus be beneficial.” So, being a permanent S spike factory is cool!
UPDATE 2022.02.25: “Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line” (CIMB, 2022.02.25): “We also show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 h upon BNT162b2 exposure.“ So, it is not a speculation any more - the mRNA from the jabs gets embedded into the transfected cells’ DNA almost immediately!
Is the spike protein mRNA in Moderna & Pfizer vaccines identical to SARS-CoV-2 mRNA? Kevin McKernan is the CSO and Founder of Medicinal Genomics. Kevin also managed the R&D for the Human Genome Project at Whitehead Institute/MIT resulting in several patents for nucleic acid purification. Kevin McKernan talks about the differences between the mRNA found in the Pfizer and Moderna COVID vaccines compared to the mRNA found in the SARS-CoV-2. This particular mRNA sequence encodes the virus spike protein.
UPDATE 2022.02.09: A post by Robert W. Malone, “A Health Public Policy Nightmare“, report on a new study on the persistence of mRNA and the produced S spike protein for AT LEAST two months post jabs, “Vaccine spike antigen and mRNA persist for two months in lymph node germinal centers... protein production of spike is higher than those of severely ill COVID-19 patients!“ There we go!
UPDATE 2022.02.10: “Self-Amplifying mRNA “Vaccines” throws in another yet-to-be-discussed possibility that the mRNA jabs use self-amplifying mRNA! “The fear I have is that it is difficult to predict how long it will stay in the body and how long the spike protein will go on (with the mRNA "vaccines"). With the self-amplifying versions, it is even more difficult to predict anything. We (our body) will be turned into a spike protein-producing factory without any clue on how long the production will go on.“
UPDATE 2022.02.11: “Evidence of connection between Severe Adverse Events and mRNA degradation” (Jessica Rose, 2022.02.11) discusses the above-referenced paper and throws in these two charts:
The brown line is the probable rate of disintegration of the mRNA and decline in S spike protein over time after the vaccination.
Just found this cool paper, Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts --https://pubmed.ncbi.nlm.nih.gov/33686748/
The mitochondria in your cells can detect foreign RNA, and downregulate protein production, increase autophagy to destroy it. The vaccine mRNA uses pseudo-uridine to defeat this recognition, and the cell just happily makes lots of spike protein.
This is related to the cell danger response, https://naviauxlab.ucsd.edu/wp-content/uploads/2020/02/Naviaux-CDR-Environmental-Health_2019.pdf
I really like this statement: I posit that the prolonged elevated level of antibodies post Covid-19 mRNA vaccination (4-7 months), is the evidence that the mRNA is active in the vaccinees’ cells for that long, producing S spike proteins and causing elevated immune reaction on the ongoing basis. When this mRNA finally wears off, it’s time for a booster!
It may explain why there is such a post-injection mortality increase that persists for months.